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KMID : 0379520020180040311
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한국독성학회지
2002 Volume.18 No. 4 p.311 ~ p.324
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Toxicokinetic Models and Data Interpretation
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Yoo Sun-Dong
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Abstract
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Toxicokinetic studies are intended to provide critical evaluation of drug disposition at toxico-logical doses and help understand the relationship between blood or tissue levels and the time course of toxic events. Relatively high dose levels wed in toxicokinetics, compared to pharmacokinetics, complicates absorption, protein binding, metabolism and elimination processes. In this mini review, frequently wed toxicokinetic models such as linear compartment models, physiological models, and nonlinear kinetic mod-ec are introduced. In addition, optimization of toxicokinetic studies, their role in the drug development process, and prediction oj human toxicokinetics based on animal data by interspecies scaling are briefly discussed.
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KEYWORD
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Toxicokinetics, Pharmacokinetics, Compartment models, Physiological models, Nonlinear kinetics, Interspecies scaling
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